Ivermectin 1%
Ivermectin is a semisynthetic, anthelmintic agent for oral
administration. Ivermectin is derived from the avermectins,
a class of highly active broad-spectrum anti-parasitic agents
isolated from the fermentation products of Streptomyces avermitilis.
Ivermectin is a mixture containing at least 90% 5-O-demethyl-22,23-dihydroavermectin
A1a and less than 10 % 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)
avermectin A1b, generally referred to as 22,23-dihydroavermectin
B1a and B1b or
H2B1a and H2B1b,
respectively. The respective empirical formulas are C48H74O14
and C47H72O14,
with molecular weights of 875.10 and 861.07, respectively.
Ivermectin is a white to yellowish-white, nonhygroscopic,
crystalline powder with a melting point of about 155°
C. It is insoluble in water but is freely soluble in methanol
and soluble in 95% ethanol.
Ivermectin is available in 5ml,10ml,25ml,50ml,100ml injection
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