Sibutramine hydrochloride monohydrate is an orally administered agent for the treatment of obesity. Chemically the active ingredient is a racemic mixture of the and enantiomers of cyclobutanemethanamine 1-(4- chlorophenyl)-N , N - dimethyl - alfa - (2-methylpropyl)-, hydrochloride, monohydrate, and has an empirical formula of C17H29Cl2NO. Its molecular weight is 334.33. Sibutramine hydrochloride monohydrate is a white to cream crystalline powder with a solubility of 2.9 mg/ mL in pH 5.2 water. Its octanol water partition coefficient is 30.9 at pH 5.0